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Description
APE Recombinant Rabbit mAb (S-R349)Product Specification Host Rabbit Synonyms DNA (apurinic or apyrimidinic site) endonuclease, APEX nuclease (APEN), Apurinic apyrimidinic endonuclease 1 (AP endonuclease 1; APE 1), REF 1, Redox factor 1, APE, APE1, APEX, APX, HAP1, Apex1 Location Nucleus Accession P27695 Clone Number S R349 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Synonyms | DNA-(apurinic or apyrimidinic site) endonuclease, APEX nuclease (APEN), Apurinic-apyrimidinic endonuclease 1 (AP endonuclease 1; APE-1), REF-1, Redox factor-1, APE, APE1, APEX, APX, HAP1, Apex1 |
| Location | Nucleus |
| Accession | P27695 |
| Clone Number | S-R349 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:500 | null |
Background
Mammalian apurinic/apyrimidinic endonuclease 1 (APEX1) is a small pleiotropic protein, which is composed of 2 distinct structural catalytic domains. The catalytic C-terminal region of APEX1 exhibits different nucleic acid enzymatic activities. Apurinic/apyrimidinic (AP) endonuclease activity is the predominant nuclease function, with a central role in the base excision repair (BER) pathway. Aside from its canonical function in DNA repair, the APEX1 nuclease domain is also implicated in transcriptional and post-translational regulation. The catalytic N-terminal protein domain of APEX1, known as redox effector function (REF-1), controls the DNA binding activity of multiple transcription factors (TFs) through modulation of their redox status.
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