SKU: 45442223080

TGF-β3 Protein, Human

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Description

TGF-β3 Protein, HumanProduct Specification Species Human Synonyms Transforming growth factor beta 3; TGF beta 3; TGF 3; Accession P10600 Amino Acid Sequence Ala301 Ser412 Expression System HEK293 Molecular Weight 11 12 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 4mM HCl Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in 4mM HCl after rapid

Product Specification


Species Human
Synonyms Transforming growth factor beta-3; TGF-beta-3; TGF-β3;
Accession P10600
Amino Acid Sequence

Ala301­-Ser412
Expression System HEK293
Molecular Weight

11-12 kDa (Reducing)
Purity >95% by SDS-PAGE and HPLC.
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized powder
Storage Buffer

4mM HCl
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in 4mM HCl after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Reference

Bone Res. 2023 Jan 2;11:2.
Sci Transl Med. 2021 Aug 4;13(605):eabe0407.

Background

TGF-beta 3 (transforming growth factor-beta 3) is a member of a TGF-beta superfamily subgroup that is defined by their structural and functional similarities. TGF-beta 3 and its closely related proteins, TGF-beta 1 and -beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial-mesenchymal transition. The non-redundant biological effects of TGF-beta 3 include involvement in palatogenesis, chondrogenesis, and pulmonary development. Human TGF-beta 3 cDNA encodes a 412 amino acid (aa) precursor that contains a 20 aa signal peptide and a 392 aa proprotein. The proprotein is processed by a furin-like convertase to generate a 220 aa latency-associated peptide (LAP) and a 112 aa mature TGF-beta 3. Mature human TGF-beta 3 shows 100%, 99%, and 98% aa identity with mouse/dog/horse, rat, and pig TGF-beta 3, respectively. TGF-beta 3 is secreted as a complex with LAP. This latent form of TGF-beta 3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin-1, and a subset of integrins. TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-beta RI or ALK-1, to modulate transcription through Smad phosphorylation. The divergent biological effects exerted by individual TGF-beta isoforms is dependent upon the recruitment of co-receptors (TGF-beta RIII and endoglin) and the subsequent initiation of Smad-dependent or -independent signaling pathways.

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Exchange/Return Notes
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SKU: 45442223080

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4.7 ★★★★★
Based on 23 reviews
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Product Reviews
D
Verified Purchase
Dani
Phoenix, US
★★★★★ 2
Not as Smart or Interactive as You Think it Will Be
Color: Blue
This is an honest review from a schnauzer owner who has has wanted this cheerble ball for their dog for more than one year. I finally bougI finally bought this toy and both me and my dog are disappointed. The settings are...i would say dog friendly as I'd assumed a dog ball would be. What I mean by that is, for example: the calm play setting is muuch too calm. Super light puffs of energy, like a battery is dying. And the playful setting is scary, alarmingly so. The intervals in between are too long. The ball does not bounce. So they just have settings all wrong. The size is good for a large dog only. Do not buy if you have a small to medium dog. I even think the material is okay. I've only had it for a few days so I can't even speak to how the material holds up. Really hoping to love this ball for my dog. It was not the distraction I was hoping it would be so I could work from home while my dog had fun. I'm hoping this can help someone else who's been pining over it. Essentially, it's a $35-$50 well made weighted ball that moves occasionally.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 9, 2026
C
Verified Purchase
Cascadian
Omaha, US
★★★★★ 5
Great For Dog Park Fun -- The Ball Goes Flying
Size: 25in, Style: Sport
I love this thing. It's super well made and It enables me to chuck a ball the entire length of the dog park (I'm a 65 yr old woman with a wimpy arm). My dog is thrilled too. At first I thought it might be too heavy, but that's just not an issue, the weight is fine. For non-throwers like me someone at the dog park gave me a tip --- just look at the area you want to throw the ball. Helped my aim immensely. The 2.5 inch chuck it ball it comes with is my dog's absolute *favorite* . . . it's her security blanket in the kennel while driving, and it's her favorite ball to chase (the only one she'll actually bring back). She loves to chew it and to squish the air out of it, which takes a little effort. Recommend.
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Reviewed in the United States on May 25, 2025
L
Verified Purchase
leal536
Cuba, US
★★★★★ 5
Great tool!
Size: 18in, Style: Sport
Ok - so I do not have a dog!!! I purchased this item for a completely different purpose! I saw someone using this to gather eggs!! I often go to my daughter and son-in-law's homestead to carry out the chores when they need to be out of town! Well, I am a bit on the short side (4'11") and some of the hens KNOW that a short person is going to be gathering eggs!!! I simply could not reach all of the eggs in a couple of the nesting boxes! So, after seeing someone else use this ball launcher as an egg retriever, I bought one! I am now able to reach ALL of the eggs - one at a time with no breakage! It was a game changer for me. I am sure that it works equally well for dog play!!!
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Reviewed in the United States on November 15, 2024
S
Verified Purchase
Steven
Cuba, US
★★★★★ 5
A Fun and Engaging Playtime Essential for Active Dogs
Size: 18in, Style: Sport
The ChuckIt! Sport 18M Dog Ball Launcher has been a game-changer in our playtime routine with our energetic and playful dog. This innovative and well-designed ball launcher has become an essential tool to keep our furry friend entertained and active. The 18" length of the launcher provides a comfortable grip for both me and my dog during play. It allows for effortless throwing, making fetch games enjoyable for both of us. The launcher's ergonomic design ensures a smooth and efficient ball-throwing experience, saving me from straining my arm during extended play sessions. The inclusion of a medium-sized ball (2.5") with the launcher is a thoughtful addition. The ball's size and weight are perfect for our medium-sized dog (20-60 pounds), allowing her to easily grab and carry it in her mouth. The ball is also durable and can withstand the enthusiastic chewing of our playful pup. One of the standout features of the ChuckIt! Sport 18M Dog Ball Launcher is its exceptional throwing distance. It allows us to launch the ball far into the distance, providing ample space for our dog to run and fetch. This extended range adds a fun and challenging element to our playtime, keeping our dog engaged and excited. The durable construction of the launcher is commendable. It has proven to withstand rigorous use and outdoor play, making it a reliable and long-lasting investment for our dog's entertainment. Additionally, the launcher's compatibility with other ChuckIt! balls makes it a versatile tool for various play styles and preferences. Whether it's a bouncy rubber ball or a flying disc, the launcher can handle them all. Moreover, using the ChuckIt! Sport 18M Dog Ball Launcher has strengthened the bond between our family and our dog. It encourages interactive play, providing an opportunity for us to engage and connect with our furry companion while promoting exercise and healthy physical activity. In conclusion, the ChuckIt! Sport 18M Dog Ball Launcher has been an absolute joy for our family and our playful dog. Its easy-to-use design, impressive throwing distance, and durability make it a must-have for any dog owner with an active and fetch-loving pet. We highly recommend the ChuckIt! Sport 18M Dog Ball Launcher, along with the included medium ball, for a fun-filled and active playtime experience that both you and your dog will love.
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Reviewed in the United States on August 3, 2023
A
Verified Purchase
Another Floyd
Belleville, US
★★★★★ 5
Essential kit for those with fetch dogs
Size: 18in, Style: Sport
Now in our 3rd year, my Brittany and I are down to about 40 fetch tosses a day, some 14,600 tosses a year. The Chuck It launcher wears well, so, figure at least 5 years of use, for 73,000 tosses. That makes for a terrific value! There are several key benefits of the Chuck It launchers: One is that you can chuck the ball further than you can throw, which allows you to exercise your dog more easily. The second is that you can pick up and launch the ball without touching it, which means NO slime! And, the Chuck It also gives extra reach when you have to retrieve a ball from sticker brambles. Those are great features for anyone with a fetch dog. If you also happen to have a weak arm or shoulder, the Chuck It launchers provide nice throwing options. I generally throw underhanded. I can't get the full potential range, that way, but, I still get good, long tosses. I curl my second finger above the last bump on the handle, and use a good wrist flick along with arm swing. I've seen others throw side-arm with the Chuck It. I had originally written a second review for the longer 25M Chuck It. Either I, or Amazon messed up, and it looks like I can have only this one review. So, here are my additional thoughts on the 25M: I bought the 25M so that I could throw the ball even further! The good news is, you really can chuck further, with the longer chucker. The bad news is, those longer throws do require more arm and shoulder strength than when using the 18M. This becomes more obvious when you've done 3 or 4 dozen throws. I would recommend the 25M only for those with the youth and/or strength to get the most out of it. Otherwise, I'd say, go with the 18M.
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Reviewed in the United States on March 11, 2016

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