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Description
IκBα Recombinant Rabbit mAb (SDT-457-9)Product Specification Host Rabbit Antigen IB Synonyms NF kappa B inhibitor alpha; I kappa B alpha; IkB alpha; IkappaBalpha; Major histocompatibility complex enhancer binding protein MAD3; NFKBIA Location Cytoplasm, Nucleus Accession P25963 Clone Number SDT 457 9 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | IκBα |
| Synonyms | NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA |
| Location | Cytoplasm, Nucleus |
| Accession | P25963 |
| Clone Number | SDT-457-9 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500 | |
| ICC | 1:100 | |
| ICFCM | 1:500 |
Background
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm [PMID: 9865693]. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning [PMID: 7590248].
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