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Description
XPO1/CRM1 Recombinant Rabbit mAb (S-3309-7)Product Specification Host Rabbit Antigen XPO1 CRM1 Synonyms Exportin 1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession O14980 Clone Number S 3309 7 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, MCF7, Jurkat, K562, NIH 3T3, RAW264. 7, PC 12, C6, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | XPO1/CRM1 |
| Synonyms | Exportin-1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | O14980 |
| Clone Number | S-3309-7 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, MCF7, Jurkat, K562, NIH/3T3, RAW264.7, PC-12, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
XPO1 (Exportin-1, also known as CRM1) is an evolutionarily highly conserved nuclear transport receptor belonging to the karyopherin-β family, primarily responsible for recognizing and binding cargo proteins containing leucine-rich nuclear export signals (NES)—including critical tumor suppressors such as p53, p21, and FOXO, as well as various oncogenic mRNAs—and actively transporting them from the nucleus to the cytoplasm in a RanGTP-dependent manner, thereby precisely regulating cell growth, division, stress responses, and apoptosis. As the "gatekeeper" of intracellular transport, XPO1 dysfunction leads to the erroneous retention and inactivation of tumor suppressors in the cytoplasm, promoting unlimited cancer cell proliferation and survival; consequently, it has emerged as a pivotal therapeutic target in oncology, where Selective Inhibitors of Nuclear Export (SINEs, e.g., Selinexor) exert their effects by covalently binding to XPO1's cargo-binding groove to block its function, forcing the re-accumulation and reactivation of tumor suppressors within the nucleus, ultimately inducing cancer cell apoptosis.
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