SKU: 26886469212

CD45 Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-R035)

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Description

CD45 Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-R035)Product Specification Host Rabbit Antigen CD45 Synonyms Leukocyte common antigen (L CA) Location Cell membrane Accession P08575 Clone Number S R035 Antibody Type Recombinant mAb Isotype IgG Application ICC, IF Reactivity Hu Purification Protein A Concentration 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 0. 1% BSA, 0. 01% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as

Product Specification


Host Rabbit
Antigen CD45
Synonyms Leukocyte common antigen (L-CA)
Location Cell membrane
Accession P08575
Clone Number S-R035
Antibody Type Recombinant mAb
Isotype IgG
Application ICC, IF
Reactivity Hu
Purification Protein A
Concentration 2 mg/ml
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer PBS, 0.1% BSA, 0.01% Proclin 300
Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
ICC 1:100-1:200
IF 1:100-1:200

Background

CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.

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Exchange/Return Notes
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SKU: 26886469212

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kay
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