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Description
SAMHD1 Recombinant Rabbit mAb (S-2401-25)Product Specification Host Rabbit Antigen SAMHD1 Synonyms Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; Dendritic cell derived IFNG induced protein (DCIP); Monocyte protein 5 (MOP 5); SAM domain and HD domain containing protein 1 (hSAMHD1); MOP5 Immunogen Synthetic Peptide Location Nucleus Accession Q9Y3Z3 Clone Number S 2401 25 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample Daudi,
Product Specification
| Host | Rabbit |
| Antigen | SAMHD1 |
| Synonyms | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; Dendritic cell-derived IFNG-induced protein (DCIP); Monocyte protein 5 (MOP-5); SAM domain and HD domain-containing protein 1 (hSAMHD1); MOP5 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q9Y3Z3 |
| Clone Number | S-2401-25 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | Daudi, Ramos |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:5000 | Hu |
| IHC-P | 1:100 | Hu |
Background
SAMHD1 (Sterile Alpha Motif and HD Domain-Containing Protein 1) is a protein that plays a crucial role in cellular processes. It is involved in the regulation of dNTP (deoxyribonucleoside triphosphate) levels within cells, which is essential for DNA synthesis and repair. SAMHD1 acts as a dNTP triphosphohydrolase, helping to maintain a balanced pool of dNTPs to prevent excessive DNA replication and genomic instability. Additionally, it has been implicated in innate immune responses, particularly in restricting the replication of certain viruses, such as HIV-1, by limiting the availability of dNTPs required for viral reverse transcription. Its dysfunction has been associated with various diseases, including Aicardi-Goutières syndrome, an autoimmune disorder characterized by chronic inflammation and neurological damage.
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