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Description
PE-Cy7 Mouse Anti-Rat CD45 Antibody (S-R591)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; Ptprc Location Cell membrane Accession P04157 Clone Number S R591 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation PE Cy7 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD45 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; Ptprc |
| Location | Cell membrane |
| Accession | P04157 |
| Clone Number | S-R591 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Rt |
Background
CD45 (also known as protein tyrosine phosphatase receptor type C, PTPRC, or leukocyte common antigen) is a type I transmembrane glycoprotein tyrosine phosphatase expressed on all nucleated hematopoietic cells except erythrocytes and plasma cells, serving as a critical regulator of T- and B-cell antigen receptor signaling through modulation of Src-family kinases and other key signaling molecules by dephosphorylating specific tyrosine residues, thereby influencing immune cell activation and differentiation; it exists in multiple isoforms generated via alternative splicing of its extracellular domain, enabling discrimination of immune cell subsets and stages of activation, and its dysregulation is implicated in immunodeficiency, autoimmunity, and malignancies.
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