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Description
IFN-alpha/beta R1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IFNAR1,IFNAR,CRF2 1,IFN R 1,IFNAR 1 Accession P17181 1 Amino Acid Sequence Target (Lys28 Lys436) with hIgG1 Fc at C Terminus Expression System HEK293 Molecular Weight 90 120 KDa(Reducing) Purity 95% by SDS PAGE &90% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Storage Buffer PBS PH7. 4 5% trehalose Stability & Storage 12 months from date of receipt, lyophilized powder stored at
Product Specification
| Species | Human |
| Synonyms | IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1 |
| Accession | P17181-1 |
| Amino Acid Sequence | Target (Lys28-Lys436) with hIgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-120 KDa(Reducing) |
| Purity | ＞95% by SDS-PAGE &＞90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Jacob RA, Zhang A, Ajoge HO, D'Agostino MR, Nirmalarajah K, Shigayeva A, Demian WL, Baker SJC, Derakhshani H, Rossi L, Nasir JA, Panousis EM, Draia AN, Vermeiren C, Gilchrist J, Smieja N, Bulir D, Smieja M, Surette MG, McArthur AG, McGeer AJ, Mubareka S, Banerjee A, Miller MS, Mossman K. Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerg Infect Dis. 2023 Jul;29(7):1386-1396. |
Background
Interferon alpha/beta receptor 1 (IFNAR1), also known as Cytokine receptor class-II member 1 (CRF2-1) or Type I interferon receptor 1, belongs to the type II cytokine receptor family. It contains four fibronectin type-III domains and pairs with IFNAR2 to form the type I interferon receptor. IFNAR1 serves as the receptor for interferons alpha and beta. Notably, IFNAR1 can transduce IFNβ signals independently of IFNAR2, without activating the Jak-STAT pathway.
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